Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Male Sexual Response: Erection & Ejaculation

Male Sexual Response: Erection & Ejaculation

Sexual stimulation can take various forms, such as physical touch and visual or auditory cues. When this happens, the parasympathetic reflex in the sacral portion of the spinal cord is activated. This reflex stimulates the release of nitric oxide (NO), which then dilates the arterioles in the penis, increasing blood flow to the erectile tissues - the corpora cavernosa and corpus spongiosum.
The blood filling the erectile tissues compresses the veins, which helps to prevent blood from leaving...

Sperm Structure and Semen Composition

Sperm Structure and Semen Composition

During ejaculation, males release around 2-5 milliliters of semen, which is a complex mixture of mature sperm and various fluids produced by accessory glands. The mature sperm cells measure approximately 60 micrometers in length and consist of a head, neck, midpiece, and tail. The head is flattened and tapered, measuring about 4 to 5 micrometers in length. It contains a nucleus with condensed chromosomes and an acrosome, a cap-like structure filled with enzymes essential for penetrating the...

Electroconvulsive Therapy

Electroconvulsive Therapy

Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early years,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Moving Equity into Practice: Evaluation of an Online Asynchronous Continuing Medical Education Program for Rheumatology Care.

Journal of medical education and curricular development·2026

Same author

Occupational History and Health Status Among Older Adults in Ecuador: Evidence from the SABE Survey.

International journal of environmental research and public health·2026

Same author

Mental Health Supports for Sexual and Gender Minorities Who Experience Intimate Partner Violence and Abuse: A Systematic Review of North American Literature.

Trauma, violence & abuse·2025

Same author

Cardiac Myxoma With Gamna-Gandy Bodies in a Nicaraguan Patient: Leveraging Advanced Imaging to Reduce Mortality Risk.

Cureus·2025

Same author

[Anaplastic Pancreatic Cancer Simulating Invasive Gastric GIST: Report of a Case with Exceptional Survival].

Revista medica de Chile·2025

Same author

Management of Surgical Aortic Valve Replacement Degeneration With Transcatheter Aortic Valve Implantation (TAVI in SAVR): Experience in Nicaragua.

Cureus·2025

Search research articles

Related Experiment Video

Updated: Jul 7, 2026

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Published on: May 30, 2025

TEMPE: Topical Eutectic-Like Mixture for Premature Ejaculation.

Richard Henry¹, Alvaro Morales, Michael G Wyllie

¹Queen's University, Department of Anesthesiology, Kingston General Hospital, 76 Stuart Street, Kingston, Ontario, K7L 2V7, Canada.

Expert Opinion on Drug Delivery

|February 6, 2008

Summary

This summary is machine-generated.

A novel topical anesthetic spray, TEMPE, shows promise for treating premature ejaculation. This formulation of lidocaine and prilocaine offers on-demand application and improved ejaculatory control.

Related Experiment Videos

Last Updated: Jul 7, 2026

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Published on: May 30, 2025

Area of Science:

Pharmacology
Dermatology
Urology

Background:

Premature ejaculation (PE) is the most common male sexual dysfunction.
Current treatments lack on-demand efficacy and rapid action.
An unmet need exists for effective, user-controlled PE pharmaceutical interventions.

Purpose of the Study:

To evaluate TEMPE, a novel topical eutectic-like mixture of lidocaine and prilocaine for premature ejaculation treatment.
To explore the potential of TEMPE for other applications, such as pain relief.

Main Methods:

TEMPE utilizes a metered-dose aerosol containing lidocaine and prilocaine in a eutectic-like mixture.
The formulation uses hydrofluoroalkane (HFA-134a) propellant as a solvent.
Optimized absorption is achieved through non-keratinized skin or mucous membranes.

Main Results:

Preliminary results indicate TEMPE improves intravaginal ejaculatory latency.
Patient-reported outcomes show promising advancements with TEMPE use.
The novel formulation ensures controlled dosing and effective local anesthetic delivery.

Conclusions:

TEMPE represents a novel therapeutic approach for premature ejaculation.
The formulation demonstrates potential for improved ejaculatory control and patient satisfaction.
Further research may explore TEMPE's utility in diverse clinical applications.