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Updated: Jul 7, 2026
Quantitation of Intra-peritoneal Ovarian Cancer Metastasis
Published on: July 18, 2016
Retrospective multicenter study of a clinicopathologic analysis of pseudomyxoma peritonei associated with ovarian
1Departments of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, Korea.
Abstract:
The purpose of this study is to assess clinicopathologic features of pseudomyxoma peritonei (PMP) that has ovarian pathology and its relationship with the prognosis. From 1995 to 2004, the clinical records and follow-up data of 35 patients with PMP, which had primarily originated from the ovary, were collected from 11 institutes of gynecologic oncology in Korea and retrospectively analyzed. All patients had ovarian lesion histologically confirmed with PMP. The mean age at diagnosis was 53.7 years (range: 16-82 years). There were 25 (71.4%) patients with disseminated peritoneal adenomucinosis, 5 (14.3%) with peritoneal mucinous carcinomatosis with intermediate group, and 5 (14.3%) with peritoneal mucinous carcinomatosis. The clinical stages at diagnosis were IA in 2 patients, IIIB in 4, IIIC in 23, IV in 1, and unknown in 5. In preoperative tumor markers, the positive rates were 72% (CA125), 47.4% (CA19-9), and 84.6% (CEA). Thirty-four patients underwent surgical staging or cytoreduction, and then 27 patients (77%) received adjuvant chemotherapy that was given to patients in a nonuniform fashion. The 5-year survival for 35 patients was 87%. Survival rate was significantly lower in patients >50 years of age (P = 0.002). Our data showed that age of the patient is the only significant prognostic factor in PMP that has ovarian lesion.
Insights
Pseudomyxoma peritonei (PMP) originating from ovarian pathology affects women, with age over 50 being the sole significant predictor of a poorer prognosis in this study.
Area of Science:
- Gynecologic Oncology
- Pathology
- Oncology
Background:
- Pseudomyxoma peritonei (PMP) is a rare condition characterized by mucinous ascites.
- Ovarian pathology is a primary source for PMP in a subset of patients.
- Understanding clinicopathologic features is crucial for prognosis.
Purpose of the Study:
- To evaluate clinicopathologic features of ovarian PMP.
- To determine the prognostic factors influencing survival in ovarian PMP.
Main Methods:
- Retrospective analysis of 35 ovarian PMP patients from 1995-2004.
- Data collected from 11 Korean gynecologic oncology institutes.
- Inclusion of histological confirmation, clinical staging, tumor markers, and survival data.
Main Results:
- The 5-year survival rate for ovarian PMP was 87%.
- Patients over 50 years old had a significantly lower survival rate (P = 0.002).
- Age was identified as the only significant prognostic factor.
Conclusions:
- Age is a critical prognostic factor in ovarian PMP.
- Further research may explore age-specific management strategies.
- This study highlights the importance of age in predicting outcomes for ovarian PMP.
