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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
Microbiome of the Eye01:22

Microbiome of the Eye

The human eye has a specialized microbiota that reflects its unique anatomical and immunological environment. This low-biomass microbial community predominantly colonizes the conjunctiva and eyelid margins, playing a vital role in ocular surface homeostasis and defense. Despite its proximity to the richly colonized facial skin, the ocular surface maintains a distinct microbial profile due to continuous mechanical and biochemical defense mechanisms.The conjunctival surface hosts fewer microbial...
Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...

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Related Experiment Video

Updated: Jul 7, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
06:15

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Periocular squamous cell carcinoma.

Maya K Thosani1, Gideon Schneck, Evan C Jones

  • 1Department of Dermatology, Stony Brook University Medical Center, Stony Brook, New York 11733, USA. maya210@gmail.com

Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [Et Al.]
|February 6, 2008
PubMed
Summary

Periocular squamous cell carcinoma is an aggressive cancer with high rates of perineural invasion and metastasis. Early diagnosis, vigilant follow-up, and appropriate surgical management are crucial for effective treatment.

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Last Updated: Jul 7, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
06:15

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Published on: August 9, 2024

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Published on: December 2, 2022

Area of Science:

  • Dermatology
  • Surgical Oncology
  • Ophthalmology

Background:

  • Periocular squamous cell carcinoma (SCC) is an aggressive malignancy.
  • It has a significant propensity for perineural involvement and regional lymphatic metastases.
  • Early diagnosis and management are critical.

Observation:

  • Periocular SCC demonstrates a significant propensity for perineural involvement.
  • Regional lymphatic metastases occur in 10% to 25% of cases, highlighting the need for increased vigilance.
  • The aggressive nature of this tumor necessitates prompt and effective therapeutic interventions.

Findings:

  • Mohs micrographic surgery or excision with frozen section analysis represents the gold standard for treating periocular SCC.
  • Various reconstructive techniques are available to restore function and cosmesis following tumor excision.
  • Emerging immunomodulatory therapies show promise for future treatment strategies.

Implications:

  • Dermatologists and dermatologic surgeons must be well-versed in the management of periocular SCC, considering its aggressive characteristics.
  • Adherence to established treatment protocols and consideration of advanced surgical techniques are vital.
  • Continued research into immunomodulation may offer novel therapeutic avenues for advanced or recurrent cases.