Growth of low birth weight preterm children

Patrick H Casey1

  • 1Department of Pediatrics, University of Arkansas for Medical Sciences, Arkansas Children's Hospital, Little Rock, AR 72202, USA. CaseyPatrick@uams.edu

Seminars in Perinatology
|February 6, 2008
PubMed

Insights

Monitoring growth in very low birth weight premature (VLBWPT) infants is crucial. Optimal growth supports better neurodevelopment, while poor or excessive gain impacts long-term health.

Area of Science:

  • Neonatal care
  • Pediatric growth and development
  • Nutritional science

Background:

  • Very low birth weight premature (VLBWPT) infants exhibit distinct early growth patterns compared to term or larger preterm peers.
  • Postnatal growth significantly influences later health and neurodevelopmental outcomes in VLBWPT children.
  • Neonatal intensive care unit (NICU) discharge requires continued monitoring of VLBWPT infant growth.

Purpose of the Study:

  • To emphasize the importance of monitoring growth velocity (weight, length, head circumference, weight/length ratio) in VLBWPT infants post-NICU discharge.
  • To highlight the neurodevelopmental and long-term health consequences of atypical growth patterns in VLBWPT children.
  • To guide nutritional planning for VLBWPT infants to achieve gradual growth normalization without excessive gain.

Main Methods:

  • Utilizing appropriate growth references to track weight, length, head circumference, and weight/length ratio over time.
  • Assessing individual growth potential considering factors like gestational age (SGA/AGA) and clinical conditions (e.g., GER, CLD).
  • Adjusting nutritional plans and caloric intake based on ongoing growth monitoring.

Main Results:

  • Atypically low weight gain is linked to suboptimal cognitive development.
  • Excessive weight gain increases the risk of obesity, cardiovascular disease, and diabetes later in life.
  • Careful nutritional planning aims for gradual growth normalization while preventing extreme weight fluctuations.

Conclusions:

  • Continuous monitoring of key growth parameters by neonatologists is essential for VLBWPT infants.
  • Nutritional strategies must balance adequate caloric intake for growth with the prevention of excessive weight gain.
  • Personalized nutritional plans, considering genetic potential and clinical status, are vital for optimizing outcomes in VLBWPT children.

Related Concept Videos

Nature and Nurture01:10

Nature and Nurture

Many human characteristics, like height, are shaped by both nature—in other words, by our genes—and by nurture, or our environment. For example, chronic stress during childhood inhibits the production of growth hormones and consequently reduces bone growth and height. Scientists estimate that 70-90% of variation in height is due to genetic differences among individuals, and 10-30% of variation in height is due to differences in the environments that individuals experience, such as differences...
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
Development of the Oral Microbiota01:28

Development of the Oral Microbiota

The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight, compared...
Development of Human Microbiota01:30

Development of Human Microbiota

The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from the skin...
Environmental Influences on Intelligence01:29

Environmental Influences on Intelligence

Despite the strong genetic influence on traits like intelligence, environmental factors significantly shape outcomes. For example, while over 90% of height variation is due to genetic differences, environmental factors such as nutrition also have a notable impact. Similarly, for intelligence, changes in a child's surroundings can significantly alter their IQ. Research shows that enriched environments boost children's academic success and help them develop key cognitive skills. Children from...