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Factors associated with adverse neurodevelopmental outcomes in infants with congenital heart disease

An N Massaro1, Mohamed El-Dib, Penny Glass

  • 1Department of Neonatology, Children's National Medical Center, 111 Michigan Avenue, NW, Washington, DC 20010, United States. anguyenm@cnmc.org

Brain & Development
|February 6, 2008
PubMed

Insights

Patients with congenital heart disease (CHD) show higher rates of neurodevelopmental impairments. Optimizing neuromonitoring and care strategies is crucial for improving long-term outcomes in this population.

Area of Science:

  • Pediatric Cardiology
  • Neurodevelopmental Pediatrics
  • Medical Outcomes Research

Background:

  • Congenital heart disease (CHD) affects neurodevelopmental outcomes.
  • Improved survival in CHD necessitates understanding long-term sequelae.
  • Neurodevelopmental impairments are more common in children with CHD.

Purpose of the Study:

  • Review neurodevelopmental outcome data in patients with CHD.
  • Identify risk factors for adverse neurodevelopmental sequelae.
  • Summarize neuromonitoring strategies for CHD patients.

Main Methods:

  • Conducted a Medline search using keywords related to CHD, neurology, and outcomes.
  • Included prospective and longitudinal studies of CHD patients.
  • Examined studies on neuroimaging, neuromonitoring, and clinical factors.

Main Results:

  • Patients with CHD exhibit increased rates of neurodevelopmental impairments.
  • Intelligence generally remains within the normal range.
  • Preoperative, intraoperative, postoperative, and neuromonitoring strategies impact long-term outcomes.

Conclusions:

  • Advances in CHD management improve survival rates.
  • Understanding neurodevelopmental outcomes is vital for optimizing care.
  • Strategies are needed to enhance long-term outcomes in high-risk CHD populations.
Abstract

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