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Related Experiment Video

Updated: Jul 7, 2026

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
08:50

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

Does histologic chorioamnionitis correspond to clinical chorioamnionitis?

Debra S Heller1, Lisa Howard Rimpel, Joan H Skurnick

  • 1DepartmentS of Pathology and Laboratory Medicine, UH/E158, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, P.O. Box 1709, Newark, NJ 07101, USA. hellerds@umdnj.edu

The Journal of Reproductive Medicine
|February 7, 2008
PubMed
Summary

Histologic chorioamnionitis, an infection of the placenta, reliably indicates maternal infection. This placental finding correlates with clinical signs of infection, even when symptoms are not apparent.

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Last Updated: Jul 7, 2026

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
08:50

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

Area of Science:

  • Obstetrics and Gynecology
  • Maternal-Fetal Medicine
  • Infectious Diseases

Background:

  • Histologic chorioamnionitis is a common placental finding.
  • Clinical indicators of maternal infection are frequently assessed during pregnancy.

Purpose of the Study:

  • To determine the correlation between histologic chorioamnionitis and clinical signs of maternal infection.

Main Methods:

  • Retrospective review of 52 cases with acute chorioamnionitis and 52 controls.
  • Analysis of maternal medical records for infection indicators.
  • Comparison of placental histology with clinical data.

Main Results:

  • Histologic chorioamnionitis showed significant association with antibiotic use (p=0.0095) and elevated white blood cell counts (p=0.018).
  • The presence of one or more clinical infection indicators was significantly linked to histologic chorioamnionitis (p=0.019).

Conclusions:

  • Histologic chorioamnionitis serves as a dependable marker for maternal infection.
  • This placental pathology is indicative of infection, regardless of clinical presentation.