Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Vascular reactivity in normal and abnormal gestation.

M Mochizuki1, H Morikawa, M Yamasaki

  • 1Department of Obstetrics and Gynecology, Kobe University School of Medicine, Japan.

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
|February 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Stable transformation of Eustoma grandiflorum by particle bombardment.

Plant cell reports·2019
Same author

Erythematous lesion with peripheral purpura on the face.

Clinical and experimental dermatology·2018
Same author

The presence of multiple NS5A RASs is associated with the outcome of sofosbuvir and ledipasvir therapy in NS5A inhibitor-naïve patients with chronic HCV genotype 1b infection in a real-world cohort.

Journal of viral hepatitis·2017
Same author

Development of non-invasive method for assessment of hepatic steatosis.

Ultrasonics·2016
Same author

L-type Ca²⁺ channel blockade with antihypertensive medication disrupts VTA synaptic plasticity and drug-associated contextual memory.

Molecular psychiatry·2015
Same author

Establishment of educational program for multiorgan procurement from deceased donors.

Transplantation proceedings·2014

Preeclampsia involves altered calcium and sodium balance, with decreased urinary calcium and increased intraplatelet calcium. Compensatory mechanisms fail, leading to increased vasoconstrictor hormones and elevated blood pressure in preeclampsia.

Area of Science:

  • Obstetrics and Gynecology
  • Cardiovascular Physiology
  • Endocrinology

Background:

  • Preeclampsia presents with heightened blood pressure response to angiotensin II.
  • Understanding the roles of calcium, sodium, and vasoactive hormones is crucial for preeclampsia research.

Purpose of the Study:

  • To investigate the involvement of calcium, sodium, membrane pumps, atrial natriuretic peptide (hANP), and endothelin in preeclampsia's vascular reactivity.
  • To elucidate the mechanisms behind increased vascular reactivity in preeclampsia.

Main Methods:

  • Analysis of urinary calcium excretion, vitamin D metabolites, serum calcium, parathyroid hormone, and intraplatelet calcium.
  • Measurement of erythrocyte sodium content and Na-K-ATPase activity.
  • Assessment of human atrial natriuretic peptide (hANP) and endothelin levels during gestation and preeclampsia.

Related Experiment Videos

Main Results:

  • Decreased urinary calcium, 1 alpha-25(OH)2D3, and serum free calcium; increased parathyroid hormone and intraplatelet calcium in preeclampsia.
  • Elevated erythrocyte sodium and reduced Na-K-ATPase activity in severe preeclampsia.
  • Increased hANP and endothelin levels in preeclampsia, with blunted hANP response to stimuli.

Conclusions:

  • Preeclampsia is associated with significant alterations in intracellular cation concentrations and membrane pump function.
  • Loss of compensatory mechanisms and increased vasoconstrictor levels contribute to enhanced vasoreactivity and hypertension in preeclampsia.
  • Further research is needed to fully understand the etiology of preeclampsia's vascular dysfunction.