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Immunocytochemistry and Immunohistochemistry

Immunocytochemistry and Immunohistochemistry

Immunocytochemistry (ICC) and immunohistochemistry (IHC) are techniques that use antibodies to check for specific proteins or antigens in a sample. The technique was first published by Albert Coons in 1941 to detect the presence of pneumococcal antigen in tissue sections from mice infected with Pneumococcus. Immunocytochemistry helps localization of proteins or antigens in individual cells like blood cells, stem cells, etc., while immunohistochemistry does the same for tissue samples.
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Updated: Jul 7, 2026

Platform for Quantitative Detection of Endometrial Immune Cells Based on Immunohistochemistry and Digital Image Analysis

Platform for Quantitative Detection of Endometrial Immune Cells Based on Immunohistochemistry and Digital Image Analysis

Published on: October 13, 2023

Immunohistochemistry in gynecologic pathology.

Michael T Deavers¹

¹Department of Pathology, Box 85, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA. mdeavers@mdanderson.org

Archives of Pathology & Laboratory Medicine

|February 7, 2008

Summary

Immunohistochemical studies aid gynecologic pathology diagnoses when routine slides are insufficient. Case studies highlight new markers and potential diagnostic pitfalls in gynecologic neoplasms.

Area of Science:

Gynecologic Pathology
Oncology
Histopathology

Background:

Most gynecologic pathology diagnoses rely on standard hematoxylin-eosin staining.
Immunohistochemistry (IHC) offers supplementary diagnostic value in select cases.
Emerging IHC markers are crucial for refining diagnoses of gynecologic neoplasms.

Observation:

This study presents case studies illustrating the application of novel IHC markers.
The focus is on challenging diagnoses within gynecologic oncology.
Potential diagnostic pitfalls associated with these new markers are identified.

Findings:

Novel immunohistochemical markers enhance diagnostic accuracy in gynecologic neoplasms.
IHC aids in differentiating tumors that are ambiguous on routine H&E staining.

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Case examples demonstrate the practical utility and limitations of specific markers.

Implications:

Incorporating new IHC markers can improve diagnostic precision in gynecologic pathology.
Awareness of potential pitfalls associated with IHC is essential for accurate diagnosis.
These findings support the integration of advanced techniques for better patient management in gynecologic cancers.