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Isolation of Primary Murine Skeletal Muscle Microvascular Endothelial Cells
11:57

Isolation of Primary Murine Skeletal Muscle Microvascular Endothelial Cells

Published on: March 6, 2019

CD1a expression in PEComas.

Yoshin Adachi1, Yasushi Horie, Yukisato Kitamura

  • 1Division of Molecular Pathology, Department of Microbiology and Pathology, Tottori University, Yonago, Japan. adcysn@grape.med.tottori-u.ac.jp

Pathology International
|February 7, 2008
PubMed
Summary

Perivascular epithelioid cell (PEComa) tumors, generally expressing melanocytic and smooth muscle markers, were investigated for CD1a expression. All PEComas studied showed CD1a expression, suggesting it as a potential new diagnostic marker.

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Area of Science:

  • Oncology
  • Pathology
  • Immunohistochemistry

Background:

  • Perivascular epithelioid cell (PEComa) tumors are a group of mesenchymal neoplasms.
  • PEComas typically exhibit immunoreactivity for melanocytic (HMB-45, melan A) and smooth muscle (alpha-SMA, desmin) markers.
  • Recent findings indicated CD1a expression in a specific type of PEComa, the clear cell sugar tumor of the lung.

Purpose of the Study:

  • To investigate the expression of CD1a in various types of PEComas.
  • To determine if CD1a can serve as an additional diagnostic marker for PEComas.

Main Methods:

  • Nineteen PEComa cases were analyzed, including angiomyolipoma, lymphangiomyomatosis, and clear cell sugar tumor.
  • Immunohistochemical staining was performed for alpha-SMA, HMB-45, melan A, and CD1a.

Main Results:

  • Eighteen out of 19 tumors expressed alpha-SMA.
  • Sixteen out of 19 tumors expressed melan A.
  • All 19 PEComa tumors demonstrated CD1a expression.

Conclusions:

  • CD1a is consistently expressed across a spectrum of PEComas.
  • CD1a expression represents a novel and valuable marker for the diagnosis of PEComas.
  • These findings support the classification of PEComas as a distinct clinicopathologic entity.