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Related Concept Videos

DNA Microarrays02:34

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...

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Related Experiment Video

Updated: Jul 7, 2026

A Next-generation Tissue Microarray (ngTMA) Protocol for Biomarker Studies
09:32

A Next-generation Tissue Microarray (ngTMA) Protocol for Biomarker Studies

Published on: September 23, 2014

Tissue microarray - a high-throughput molecular analysis in head and neck cancer.

Raghu Radhakrishnan1, Monica Solomon, Kapaettu Satyamoorthy

  • 1Department of Oral Pathology, MCODS, MAHE, Manipal, India. raghu.radhakrishnan@gmail.com

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
|February 7, 2008
PubMed
Summary

Tissue microarray (TMA) technology enables high-throughput analysis of numerous cancer tissue samples. This review highlights TMA

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Area of Science:

  • Oncology
  • Pathology
  • Biotechnology

Background:

  • Novel diagnostic, prognostic, and therapeutic markers are increasingly identified in cancer research.
  • Validating these markers requires efficient, large-scale analysis of clinical tissue samples.
  • Tissue Microarray (TMA) technology offers a solution for high-throughput sample analysis.

Purpose of the Study:

  • To review the technology, construction, and validity of Tissue Microarray (TMA) applications in cancer research.
  • To highlight the utility of TMA for validating candidate markers.
  • To focus on the application of TMA in oral pathology diagnostics, particularly for head and neck cancer.

Main Methods:

  • Review of recent literature on Tissue Microarray (TMA) technology and its applications.
  • Focus on technical aspects of TMA construction.
  • Evaluation of TMA result validity in oral pathology diagnostics.

Main Results:

  • Tissue Microarray (TMA) is a robust high-throughput technique for analyzing hundreds of archival clinical tissue samples.
  • TMA facilitates large-scale validation of novel cancer markers.
  • TMA demonstrates validity for oral pathology diagnostics, especially in head and neck cancer research.

Conclusions:

  • Tissue Microarray (TMA) is an invaluable tool for cancer research, marker validation, and diagnostics.
  • The technology's high-throughput nature and robust methodology support its application in oral pathology.
  • TMA significantly aids in the advancement of head and neck cancer research and diagnostics.