Related Experiment Video
Updated: Jul 7, 2026
11:30
A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
Published on: June 2, 2022
Calcium balance during hemodialysis.
1Division of Vascular Medicine, University of Nottingham Medical School, Derby, United Kingdom. chris.mcintyre@nottingham.ac.uk
Seminars in Dialysis
|February 7, 2008
Summary
Maintaining proper calcium balance during hemodialysis is crucial for cardiovascular health and preventing vascular calcification. This review covers calcium flux, dialysate concentration, and treatment choices impacting patient outcomes.
Area of Science:
- Nephrology
- Cardiovascular Medicine
- Mineral Metabolism
Background:
- Calcium balance is critical for hemodialysis (HD) patients, affecting both short-term hemodynamic stability and long-term health.
- Intradialytic calcium flux impacts overall calcium balance, potentially influencing vascular calcification and its complications.
Purpose of the Study:
- To review the assessment and mechanisms of calcium flux during hemodialysis.
- To discuss the impact of dialysate calcium concentration and HD modality on calcium balance.
- To explore the cardiovascular and skeletal consequences of inappropriate intradialytic calcium management.
Main Methods:
- Literature review of studies on calcium balance and hemodialysis.
- Analysis of factors influencing intradialytic calcium flux.
- Examination of clinical outcomes related to calcium management in HD.
Main Results:
- Hemodynamic tolerability of HD is linked to short-term calcium balance.
- Long-term calcium balance during HD influences vascular calcification progression.
- Dialysate calcium concentration and HD modality significantly affect calcium flux.
Conclusions:
- Optimizing intradialytic calcium balance is essential for managing cardiovascular and skeletal health in HD patients.
- Careful consideration of dialysate calcium and HD modality is necessary to prevent adverse outcomes.
- Further research into precise calcium management strategies is warranted.
Related Concept Videos
01:25Hemodialysis III: Nursing Management
The nursing management of a patient undergoing hemodialysis includes several critical steps, starting with a thorough assessment before the procedure.Before the Hemodialysis ProcedureFirst, record the patient's vital signs—blood pressure, heart rate, respiratory rate, and temperature—to establish a baseline. This baseline is essential for detecting conditions such as hypotension that could impact the patient's response to dialysis. Document the patient's pre-dialysis weight, as this measurement...
01:21Skeleton and Calcium Homeostasis
Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
01:24Hemodialysis II: Procedure and Complications
DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
01:28Chronic Kidney Disease III: Interprofessional Care
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
01:29Renal Regulation of Acid-Base Balance
Metabolic reactions in the body produce nonvolatile acids, such as sulfuric acid, which generate an acid load of approximately 1 mEq of H+ per kilogram of body weight daily. Excreting H+ in the urine is essential to balance this acid load.
In the kidneys, cells within the proximal convoluted tubules (PCT) and the collecting ducts secrete hydrogen ions (H+) into the tubular fluid. Specifically, in the PCT, Na+/H+ antiporters secrete H+ while reabsorbing Na+.
However, the intercalated cells in...
In the kidneys, cells within the proximal convoluted tubules (PCT) and the collecting ducts secrete hydrogen ions (H+) into the tubular fluid. Specifically, in the PCT, Na+/H+ antiporters secrete H+ while reabsorbing Na+.
However, the intercalated cells in...
01:25Hemodialysis I: Introduction
Hemodialysis (HD) is a medical treatment that artificially removes waste products, excess fluids, and toxins from the blood when the kidneys are no longer able to perform these functions effectively. In this process, blood is filtered through a semipermeable membrane, allowing for the selective removal of waste while preserving necessary components like blood cells and proteins. Hemodialysis is typically performed in patients with end-stage renal disease (ESRD) or severe kidney...