Reduced sensitivity of influenza A (H5N1) to oseltamivir
Jennifer L McKimm-Breschkin1, Paul W Selleck, Tri Bhakti Usman
1CSIRO Molecular and Health Technologies, Parkville, Victoria, Australia. jennifer.mckimm-breschkin@csiro.au
Emerging Infectious Diseases
|February 7, 2008
Abstract:
We tested the neuraminidase drug sensitivity of clade 1 and clade 2 influenza A (H5N1). All viruses demonstrated similar sensitivity to zanamivir, but compared with the 2004 clade 1 viruses, the Cambodian 2005 viruses were 6-fold less sensitive and the Indonesian clade 2 viruses were up to 30-fold less sensitive to oseltamivir.
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