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Related Concept Videos

Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
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Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
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Related Experiment Video

Updated: Jul 7, 2026

Experimental Endocarditis Model of Methicillin Resistant Staphylococcus aureus (MRSA) in Rat
07:46

Experimental Endocarditis Model of Methicillin Resistant Staphylococcus aureus (MRSA) in Rat

Published on: June 4, 2012

Methicillin-resistant Staphylococcus aureus in pigs with exudative epidermitis.

Engeline van Duijkeren1, Marc D Jansen, S Carolien Flemming

  • 1Utrecht University, Utrecht, The Netherlands. e.vanduijkeren@vet.uu.nl

Emerging Infectious Diseases
|February 7, 2008
PubMed
Summary

Methicillin-resistant Staphylococcus aureus (MRSA) was found in piglets, pigs, and farm workers in the Netherlands, despite strict human MRSA controls. Indistinguishable strains suggest direct transmission between animals and humans on these farms.

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Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
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Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Published on: February 9, 2011

Related Experiment Videos

Last Updated: Jul 7, 2026

Experimental Endocarditis Model of Methicillin Resistant Staphylococcus aureus (MRSA) in Rat
07:46

Experimental Endocarditis Model of Methicillin Resistant Staphylococcus aureus (MRSA) in Rat

Published on: June 4, 2012

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Published on: February 9, 2011

Area of Science:

  • Veterinary Medicine
  • Infectious Diseases
  • Public Health

Background:

  • Strict control programs for methicillin-resistant Staphylococcus aureus (MRSA) are in place in human medicine in the Netherlands.
  • MRSA poses a significant threat to both animal and human health, necessitating surveillance in all settings.

Purpose of the Study:

  • To investigate the presence and potential transmission of MRSA in swine populations and associated farm workers.
  • To determine if MRSA strains found in animals are related to those in humans.

Main Methods:

  • Culturing of MRSA from exudative epidermitis lesions in piglets and pigs.
  • Sampling and culturing of MRSA from farm workers.
  • Molecular typing of MRSA strains to assess relatedness.

Main Results:

  • MRSA was detected in 4 piglets and 20 pigs across two farms.
  • MRSA was also identified in 2 workers on these farms.
  • All identified MRSA strains were indistinguishable, indicating a common source or direct transmission.

Conclusions:

  • MRSA is present in the Dutch swine population and can transmit to farm workers.
  • The findings highlight the need for integrated surveillance and control strategies for MRSA across human and animal populations.
  • Despite existing human MRSA control programs, animal-to-human transmission remains a concern.