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Related Concept Videos

Infertility in Males01:23

Infertility in Males

Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents01:29

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel Disease...
Menopause01:28

Menopause

Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
Spermatogenesis01:41

Spermatogenesis

Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male reproductive...
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Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment

Hepatic impairment, characterized by decreased liver function, does not uniformly mandate adjustments in drug dosage. Whether dosage modifications are necessary depends on various factors related to the drug's metabolism and elimination pathways. If a drug is primarily excreted via the kidneys and bypasses significant hepatic processing, if it undergoes minimal metabolic transformation in the liver, or if it is volatile and primarily expelled through the lungs, dose adjustments may not be...

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Related Experiment Video

Updated: Jul 7, 2026

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility
04:22

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Published on: May 30, 2025

[Impotence caused by Methotrexate treatment].

Elisabeth I Penninga1, Helle Kiellberg Larsen, Stig Ejdrup Andersen

  • 1Klinisk Farmakologisk Enhed, Bispebjerg Hospital, DK-2400 København NV. ip08@bbh.hosp.dk.

Ugeskrift for Laeger
|February 7, 2008
PubMed
Summary

Methotrexate (MTX) treatment can cause erectile impotence, a rare side effect. This case report highlights the reversible nature of MTX-induced impotence, emphasizing its potential as an overlooked adverse effect.

Related Experiment Videos

Last Updated: Jul 7, 2026

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility
04:22

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Published on: May 30, 2025

Area of Science:

  • Pharmacology
  • Toxicology
  • Dermatology

Background:

  • Methotrexate (MTX) is a widely used drug for treating various malignant and non-malignant conditions.
  • Erythrodermia is a severe skin condition requiring systemic treatment.
  • Adverse drug reactions require careful monitoring and reporting.

Observation:

  • A 58-year-old male patient with erythrodermia was treated with weekly methotrexate (7.5 mg).
  • The patient developed erectile impotence approximately nine months after commencing MTX therapy.
  • Impotence resolved upon MTX discontinuation and recurred upon its reintroduction.

Findings:

  • This case report documents a rare adverse effect of methotrexate: erectile impotence.
  • The temporal relationship and recurrence upon re-challenge strongly suggest MTX as the causative agent.
  • Previous literature has sparsely reported similar cases of MTX-associated impotence.

Implications:

  • Clinicians should consider erectile dysfunction as a potential adverse effect of methotrexate treatment.
  • Further investigation into the mechanisms of MTX-induced sexual dysfunction may be warranted.
  • This case underscores the importance of comprehensive patient monitoring for all potential side effects of systemic medications.