Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Thyroid function in severely disabled children].

M Kimura1, M Kato, K Yoshino

  • 1Department of Pediatrics, National Sanatorium, Nishi-Tottori Hospital.

No to Hattatsu = Brain and Development
|January 1, 1991
PubMed
Summary

Thyroid function abnormalities are common in severely disabled children, often linked to anticonvulsant medications. Supplementation with L-thyroxine did not improve symptoms in patients with low thyroid hormone levels.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of a matrix metalloproteinase inhibitor on host resistance against Listeria monocytogenes infection.

FEMS immunology and medical microbiology·2000
Same author

PCGEM1, a prostate-specific gene, is overexpressed in prostate cancer.

Proceedings of the National Academy of Sciences of the United States of America·2000
Same author

Ectodomain shedding of epidermal growth factor receptor ligands is required for keratinocyte migration in cutaneous wound healing.

The Journal of cell biology·2000
Same author

Immunohistochemical localization of telomerase hTERT protein and analysis of clonality in multifocal vulvar intraepithelial neoplasia.

American journal of clinical pathology·2000
Same author

Placental transfer of IgG subclasses in a Japanese population.

Pediatrics international : official journal of the Japan Pediatric Society·2000
Same author

Carboxyl-terminal region conserved among phosphoinositide-kinase-related kinases is indispensable for mTOR function in vivo and in vitro.

Genes to cells : devoted to molecular & cellular mechanisms·2000

Area of Science:

  • Pediatric Endocrinology
  • Clinical Chemistry
  • Neurology

Context:

  • Thyroid dysfunction evaluation in pediatric populations.
  • Impact of chronic illness and medication on endocrine function.
  • Assessment of thyroid hormone levels in severely disabled children.

Purpose:

  • To investigate the prevalence and causes of thyroid function abnormalities in severely disabled children.
  • To determine the relationship between anticonvulsant use and thyroid hormone levels.
  • To evaluate the efficacy of L-thyroxine supplementation in affected children.

Summary:

  • Fifty-three percent of 105 severely disabled children exhibited abnormal thyroid function tests.
  • Anticonvulsant medications were identified as the primary cause of these abnormalities, with serum T4 levels correlating with the number of anticonvulsants used.

Related Experiment Videos

  • Two cases of primary hypothyroidism and two suspected cases of subclinical hypothalamic-pituitary hypothyroidism due to septo-optic dysplasia were identified.
  • L-thyroxine supplementation in four patients with low T4 or low T4/T3 levels yielded no clinical improvement, with decreased TSH and hyporeaction on TRH testing observed.
  • Low T3 syndrome, unrelated to anticonvulsants, was noted in two patients with poor nutritional status.

    • Impact:

    • Highlights the significant prevalence of thyroid dysfunction in severely disabled children.
    • Underscores the etiological role of anticonvulsant drugs in pediatric thyroid abnormalities.
    • Suggests limitations of L-thyroxine supplementation in certain thyroid dysfunction scenarios within this population.
    • Informs clinical practice regarding thyroid monitoring and management in neurologically impaired children.