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Related Concept Videos

Inflammation01:38

Inflammation

Overview
Acute Inflammation III: Local and Systemic Effects01:25

Acute Inflammation III: Local and Systemic Effects

Acute inflammation produces a coordinated set of local and systemic changes that limit injury, eliminate pathogens, and initiate repair. These responses arise within minutes of infection, trauma, or chemical insult and are driven by vascular alterations and leukocyte-derived mediators. When the stimulus resolves, the reaction typically abates within days.Local EffectsAt the site of injury, arteriolar vasodilation increases blood flow, resulting in redness and warmth. Simultaneously, increased...
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Inflammatory Response01:28

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...

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Related Experiment Video

Updated: Jul 7, 2026

Assessment of Vascular Regeneration in the CNS Using the Mouse Retina
07:32

Assessment of Vascular Regeneration in the CNS Using the Mouse Retina

Published on: June 23, 2014

Post-ischaemic neovascularization and inflammation.

Jean-Sebastien Silvestre1, Ziad Mallat, Alain Tedgui

  • 1Cardiovascular Research Center, Inserm Lariboisiere, Inserm U689, Universite Paris 7, Hôpital Lariboisière, 41 Bd de la Chapelle, 75475 Paris cedex 10, France. jean-sebastien.silvestre@larib.inserm.fr

Cardiovascular Research
|February 7, 2008
PubMed
Summary

Inflammation drives new blood vessel growth (neovascularization) in ischaemic vascular diseases. Understanding these inflammatory pathways is key to developing treatments for tissue repair and remodelling.

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Last Updated: Jul 7, 2026

Assessment of Vascular Regeneration in the CNS Using the Mouse Retina
07:32

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Published on: June 23, 2014

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Area of Science:

  • Vascular Biology
  • Ischaemic Diseases
  • Inflammation Research

Background:

  • Tissue repair in ischaemic vascular diseases involves vasculogenesis, angiogenesis, arteriogenesis, and collateral growth.
  • The interplay and relative importance of these vascular repair processes are not fully understood.
  • Distinct yet overlapping cellular and molecular pathways regulate these distinct growth mechanisms.

Purpose of the Study:

  • To summarize current knowledge on the inflammatory response in ischaemia.
  • To review key factors involved in inflammation-induced, post-ischaemic neovascularization.

Main Methods:

  • Literature review of inflammatory responses in ischaemia.
  • Analysis of cellular and molecular pathways driving neovascularization.
  • Synthesis of information on inflammation-induced vessel growth.

Main Results:

  • Inflammation is a significant stimulus for initiating neovascularization in ischaemic conditions.
  • Specific cellular and molecular factors mediate inflammation-induced vessel growth.
  • Multiple vascular repair processes contribute to tissue remodelling.

Conclusions:

  • Inflammation plays a critical role in post-ischaemic neovascularization.
  • Targeting inflammation may offer therapeutic strategies for ischaemic vascular diseases.
  • Further research is needed to elucidate the precise roles of different vascular repair processes.