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Related Experiment Video

Updated: Jul 7, 2026

Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis
03:23

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Published on: May 10, 2024

Age-related changes in eosinophil function in human subjects.

Sameer K Mathur1, Elizabeth A Schwantes, Nizar N Jarjour

  • 1Section of Allergy, Pulmonary and Critical Care, Department of Medicine, University of Wisconsin School of Medicine and Public Health, K4/910 Clinical Sciences Center, 600 Highland Ave, Madison, WI 53792, USA. sm4@medicine.wisc.edu

Chest
|February 7, 2008
PubMed
Summary
This summary is machine-generated.

Older adults with asthma show reduced eosinophil degranulation, impacting immune responses. This age-related change in eosinophil function may alter asthma manifestations and treatment effectiveness in the elderly.

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Published on: July 28, 2016

Area of Science:

  • Immunology
  • Gerontology
  • Respiratory Medicine

Background:

  • Aging alters immune cell function, but age-related changes in eosinophils remain largely undefined.
  • Eosinophils play a role in inflammatory diseases like asthma.

Purpose of the Study:

  • To investigate age-related changes in human eosinophil function.
  • To explore the implications of these changes for asthma patients.

Main Methods:

  • Recruited adult asthma patients into younger (20-40 years) and older (55-80 years) groups.
  • Assessed lung function, sputum, and peripheral blood.
  • Examined in vitro eosinophil degranulation, superoxide anion production, adhesion, and chemotaxis.

Main Results:

  • Older adults had significantly decreased eosinophil degranulation in response to interleukin-5.
  • Superoxide anion production was lower in older adults but not statistically significant.
  • Eosinophil adhesion, chemotaxis, lung function, and sputum eosinophil counts were similar between age groups.

Conclusions:

  • Airway eosinophil counts are comparable in younger and older asthma patients.
  • Peripheral blood eosinophil effector functions exhibit age-related declines.
  • Age-associated changes in eosinophil function may influence asthma clinical presentation and medication response in older individuals.