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Updated: Jul 7, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Two quinazolinones: a ring conformational study
G Y S K Swamy1, B Sridhar, K Ravikumar
1Laboratory of X-ray Crystallography, Indian Institute of Chemical Technology, Hyderabad 500 007, India. swamy@iict.res.in
Abstract:
The molecules of (+/-)-2-(4-methoxyphenyl)-1-phenethyl-2,3-dihydroquinazolin-4(1H)-one, C(23)H(22)N(2)O(2), (I), and (+/-)-2-(1,3-benzodioxol-5-yl)-1-phenethyl-2,3-dihydroquinazolin-4(1H)-one, C(23)H(20)N(2)O(3), (II), have T-shaped forms in the crystal structure. The tetrahydropyrimidine ring in both structures adopts a sofa conformation. Both molecules are linked by N-H...O and C-H...O hydrogen bonds to form sheets built from alternating R(2)(2)(8) and R(4)(4)(26) [R(4)(4)(24) in (II)] edge-fused rings. Additionally, the structures are stabilized by extensive C-H...pi interactions.
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