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A Catheter-Related Candida albicans Infection Model in Mouse
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Cryptococcosis associated with crescentic glomerulonephritis.

Marta Suárez-Rivera1, Rania A Abadeer, Marylee M Kott

  • 1Department of Pediatrics, Division of Pediatric Nephrology and Hypertension, University of Texas Health Science Center-Houston, 6431 Fannin Street, Houston, TX 77030, USA.

Pediatric Nephrology (Berlin, Germany)
|February 7, 2008
PubMed
Summary

This case report details an 11-year-old girl with crescentic glomerulonephritis (CGN) and cryptococcal mediastinitis. The unusual presentation highlights a rare link between fungal infections and kidney disease in children.

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Last Updated: Jul 7, 2026

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Published on: March 22, 2024

Area of Science:

  • Pediatric Nephrology
  • Infectious Diseases
  • Immunology

Background:

  • Crescentic glomerulonephritis (CGN) is a rare but severe kidney disease in children.
  • Fungal infections are not typically associated with CGN.
  • Cryptococcal infections in children usually indicate underlying immunodeficiency.

Observation:

  • An 11-year-old girl presented with CGN, cutaneous anergy, and cryptococcal mediastinitis.
  • Immunologic evaluation revealed relative CD4 lymphopenia but no HIV infection.
  • The patient's presentation was unusual given the lack of significant immunodeficiency.

Findings:

  • The case demonstrates a rare association between cryptococcal infection and CGN in a child.
  • Diagnostic studies and clinical presentation are detailed.
  • Literature review on glomerular disease and cryptococcal infections is included.

Implications:

  • This case expands the understanding of potential triggers for CGN in pediatric populations.
  • It suggests that fungal infections, like cryptococcosis, should be considered in the differential diagnosis of unexplained CGN in children.
  • Further research may be needed to elucidate the mechanisms linking fungal infections to glomerular injury.