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Related Experiment Videos

Buflomedil for intermittent claudication.

T L M de Backer1, M Bogaert, R Vander Stichele

  • 1Ghent University, Heymans Institute of Pharmacology, De Pintelaan 185, Gent, Belgium B-9000. tine.debacker@ugent.be

The Cochrane Database of Systematic Reviews
|February 7, 2008
PubMed
Summary
This summary is machine-generated.

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Buflomedil offers a small, statistically significant improvement in walking distance for intermittent claudication (IC). However, limited evidence and safety concerns, alongside publication bias, question its overall clinical benefit for peripheral vascular disease.

Area of Science:

  • Vascular Medicine
  • Pharmacology
  • Clinical Trials

Background:

  • Intermittent claudication (IC) is a symptom of peripheral vascular disease causing exercise-induced limb pain.
  • Buflomedil, a vasoactive agent, is used for peripheral vascular disease, but its efficacy for IC requires evaluation.

Purpose of the Study:

  • To critically examine the available evidence on the clinical efficacy of buflomedil for treating intermittent claudication (IC).

Main Methods:

  • Systematic review of randomized controlled trials (RCTs) comparing oral buflomedil to placebo in IC patients (Fontaine stage II).
  • Searched multiple databases (Cochrane, MEDLINE, IPA, SCI) and contacted manufacturers for data.
  • Analyzed pain-free walking distance (PFWD) and maximum walking distance (MWD) using standardized exercise tests.

Related Experiment Videos

Main Results:

  • Two RCTs with 127 participants met the inclusion criteria.
  • Buflomedil showed moderate, statistically significant improvements in PFWD and MWD compared to placebo.
  • Improvements were observed in both general IC and a wholly diabetic population, though confidence intervals for MWD were wide.

Conclusions:

  • Limited high-quality evidence exists for buflomedil's efficacy in IC.
  • Positive results from the two included trials are potentially undermined by publication bias due to unpublished studies.
  • Buflomedil's benefits appear small relative to safety concerns and its narrow therapeutic index.