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Related Experiment Videos

Colloid solutions for fluid resuscitation.

F Bunn1, D Trivedi, S Ashraf

  • 1University of Hertfordshire, Centre for Research in Primary and Community Care (CRIPACC), College Lane, Hatfield, Hertfordshire, UK AL10 9PN. f.bunn@herts.ac.uk

The Cochrane Database of Systematic Reviews
|February 7, 2008
PubMed
Summary
This summary is machine-generated.

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This review found no evidence that one colloid solution is more effective or safe than another for fluid volume replacement. Larger trials are needed to detect potential differences in mortality between colloid solutions.

Area of Science:

  • Critical Care Medicine
  • Pharmacology
  • Fluid Therapy

Background:

  • Colloids are frequently used for fluid volume replacement.
  • Concerns exist regarding the optimal choice of colloid due to variations in molecular weight, circulatory residence time, safety, and efficacy.

Purpose of the Study:

  • To compare the effects of different colloid solutions in patients requiring volume replacement.

Main Methods:

  • A systematic review of randomized and quasi-randomized trials was conducted.
  • Searches included major databases (MEDLINE, EMBASE, CENTRAL) and contact with drug manufacturers.
  • Outcomes assessed were mortality, blood transfusion requirements, and adverse reactions.

Main Results:

Related Experiment Videos

  • Seventy trials involving 4375 participants were analyzed.
  • No significant differences in mortality were found between albumin/plasma protein fraction (PPF) and hydroxyethyl starch (HES), gelatin, or dextran.
  • While no adverse reactions were reported, wide confidence intervals indicate potential for clinically significant differences.

    • Conclusions:

    • Current evidence does not support one colloid solution being superior to another in terms of safety or efficacy.
    • Further large-scale trials are necessary to definitively establish or exclude clinically significant differences in mortality associated with colloid use.