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Related Experiment Video

Updated: Jul 7, 2026

A Retrospective Study on Endoscopic Surgery for the Treatment of Paravertebral Abscess in Spinal Tuberculosis Patients

A Retrospective Study on Endoscopic Surgery for the Treatment of Paravertebral Abscess in Spinal Tuberculosis Patients

Published on: October 25, 2024

Corticosteroids for managing tuberculous meningitis.

K Prasad¹, M B Singh

¹All India Institute of Medical Sciences, Department of Neurology, Ansarinagar, New Delhi, India 110029. drkameshwarprasad@yahoo.co.in

The Cochrane Database of Systematic Reviews

|February 7, 2008

Summary

Corticosteroids reduce the risk of death and severe disability in tuberculous meningitis patients. Routine use is recommended for HIV-negative individuals, but evidence for HIV-positive patients is insufficient.

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Last Updated: Jul 7, 2026

A Retrospective Study on Endoscopic Surgery for the Treatment of Paravertebral Abscess in Spinal Tuberculosis Patients

A Retrospective Study on Endoscopic Surgery for the Treatment of Paravertebral Abscess in Spinal Tuberculosis Patients

Published on: October 25, 2024

Area of Science:

Infectious Diseases
Neurology
Clinical Medicine

Background:

Tuberculous meningitis (TBM) is a severe form of tuberculosis with high mortality and disability rates.
The efficacy of corticosteroids as an adjunct treatment for TBM remains controversial.

Purpose of the Study:

To evaluate the impact of corticosteroids on mortality and severe disability in patients with tuberculous meningitis.

Main Methods:

Systematic review and meta-analysis of randomized controlled trials.
Searched multiple databases including Cochrane, MEDLINE, and EMBASE.
Analyzed data using relative risks and a fixed-effect model.

Main Results:

Seven trials with 1140 participants were included.
Corticosteroids significantly reduced the risk of death (RR 0.78, 95% CI 0.67 to 0.91).
Corticosteroids also reduced the risk of death or disabling neurological deficit (RR 0.82, 95% CI 0.70 to 0.97).

Conclusions:

Corticosteroids should be routinely used in HIV-negative TBM patients.
Evidence is insufficient to recommend corticosteroids for HIV-positive TBM patients.