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Antioxidants for preventing pre-eclampsia.

A Rumbold1, L Duley, C A Crowther

  • 1Menzies School of Health Research, PO Box 41096, Casuarina, NT, Australia, 0820. alice.rumbold@menzies.edu.au

The Cochrane Database of Systematic Reviews
|February 7, 2008
PubMed
Summary
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Antioxidant supplementation during pregnancy does not significantly reduce the risk of pre-eclampsia or related complications. This review found no evidence to support routine use of antioxidants for preventing pre-eclampsia.

Area of Science:

  • Obstetrics and Gynecology
  • Perinatal Medicine
  • Nutritional Science

Background:

  • Oxidative stress is implicated in pre-eclampsia development.
  • Antioxidant supplementation in pregnancy may counteract oxidative stress.
  • Potential to prevent or delay pre-eclampsia onset.

Purpose of the Study:

  • Evaluate antioxidant supplementation effectiveness during pregnancy.
  • Assess safety of antioxidant use.
  • Determine impact on pre-eclampsia risk and complications.

Main Methods:

  • Systematic review of randomized controlled trials.
  • Searched Cochrane, MEDLINE, and Current Contents databases.
  • Included trials comparing antioxidants with placebo or no treatment.

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Main Results:

  • Ten trials (6533 women) analyzed; five high-quality.
  • No significant difference in pre-eclampsia, severe pre-eclampsia, preterm birth, or infant death rates.
  • Increased self-reported abdominal pain and need for antihypertensive therapy observed.

Conclusions:

  • Current evidence does not support routine antioxidant supplementation in pregnancy.
  • No demonstrated benefit for reducing pre-eclampsia or serious pregnancy complications.
  • Further research may be needed to clarify specific roles or populations.