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Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria
11:32

Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria

Published on: February 23, 2014

[Prognostic factors of pneumococcal meningitis. Retrospective study of 31 cases]

H Kallel1, I Mâaloul, F Mahjoubi

  • 1Service de Réanimation Médicale, CHU Habib Bourguiba, Sfax, Tunisie.

La Tunisie Medicale
|February 8, 2008
PubMed
Abstract

Insights

In pneumococcal meningitis, penicillin G resistance does not worsen outcomes. However, older age, low albumin, shock, and low Glasgow Coma Score predict a poorer prognosis.

Area of Science:

  • Infectious Diseases
  • Neurology
  • Clinical Microbiology

Context:

  • Pneumococcal meningitis remains a significant cause of mortality and morbidity worldwide.
  • Antibiotic resistance in Streptococcus pneumoniae poses a challenge to effective treatment.
  • Understanding prognostic factors is crucial for managing patients with pneumococcal meningitis.

Purpose:

  • To investigate the antibiotic susceptibility of Streptococcus pneumoniae in meningitis cases.
  • To identify prognostic factors associated with mortality in pneumococcal meningitis patients.

Summary:

  • A retrospective study of 31 pneumococcal meningitis cases revealed that Streptococcus pneumoniae resistance to penicillin G was observed in 33% of isolates.
  • Hospital mortality was 26%. Factors significantly associated with death included age ≥55 years, albuminorachie ≥7 g/l, shock, and Glasgow Coma Score (GCS) ≤8.
  • Penicillin G resistance was not found to be associated with a worse outcome.

Impact:

  • This study highlights key clinical indicators for predicting outcomes in pneumococcal meningitis.
  • Findings emphasize the importance of early recognition of prognostic factors for timely intervention.
  • The data contributes to understanding the clinical implications of antibiotic resistance in Streptococcus pneumoniae meningitis.

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