The insidious nature and presentation of oral squamous cell carcinoma in the low-risk population
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Updated: Jul 7, 2026

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
Shawn A Jepsen1, James J Closmann
1Tripler Army Medical Center, Hawaii, USA.
Abstract:
Oral squamous cell carcinoma is found predominantly in patients who have a history of smoking, alcohol consumption, or betel quid use. However, some of these patients have no known risk factors for development of the lesion and sometimes are diagnosed later in life due to low clinical suspicion of squamous cell carcinoma. This article presents three such cases, including their history and treatment.
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