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A stable isotope dilution mass spectrometric assay for the major urinary metabolite of PGD2
J D Morrow1, C Prakash, T A Duckworth
1Department of Pharmacology, Vanderbilt University, Nashville, TN 37232-6602.
Advances in Prostaglandin, Thromboxane, and Leukotriene Research
|January 1, 1991
Abstract:
1. A sensitive and specific negative ion chemical ionization mass spectrometric assay for the major urinary metabolite of PGD2 has been developed employing a chemically synthesized [18(0)4]-labelled internal standard. 2. The finding that increased urinary excretion of this metabolite occurs in a number of clinical situations suggests that the assay may prove to be a valuable tool to explore the role of PGD2 in the pathophysiology of human disease.