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Occupational triphenyltin acetate poisoning: a case report
C Colosio1, M Tomasini, S Cairoli
1Istituto di Medicina del Lavoro, Università degli Studi di Milano, Italia.
British Journal of Industrial Medicine
|February 1, 1991
Summary
Triphenyltin acetate (TPTA) poisoning caused skin issues, liver damage, and abnormal brain activity. TPTA exposure impaired neutrophil function, affecting the immune response to infection.
Area of Science:
- Toxicology
- Immunology
- Environmental Health
Background:
- Triphenyltin acetate (TPTA) is an organotin compound with potential toxicity.
- Occupational or environmental exposure can lead to adverse health effects.
Observation:
- A case of acute TPTA poisoning via cutaneous absorption is detailed.
- The patient presented with urticarial rash, hepatic injury, glucose intolerance, and EEG abnormalities.
Findings:
- Neutrophil actin polymerization was inhibited following stimulation with fMLP during peak TPTA exposure.
- Urinary tin excretion exhibited biphasic kinetics, suggesting potential accumulation.
Implications:
- TPTA exposure can compromise immune cell function, increasing infection risk.
- Understanding TPTA toxicokinetics is crucial for managing poisoning cases and assessing long-term health risks.