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Related Experiment Video

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Morphometric Analyses of Shape: The Analysis Software Toolbox for Craniofacial Shape Quantification in Zebrafish

Morphometric Analyses of Shape: The Analysis Software Toolbox for Craniofacial Shape Quantification in Zebrafish

Published on: February 27, 2026

Linear mixed models for longitudinal shape data with applications to facial modeling.

Sarah J E Barry¹, Adrian W Bowman

¹Department of Statistics, University of Glasgow, 15 University Gardens, Glasgow G12 8QW, UK. sarah@stats.gla.ac.uk

Biostatistics (Oxford, England)

|February 8, 2008

Summary

This study applies advanced statistical methods to analyze facial shape changes in infants with cleft lip and palate compared to controls. The findings offer objective assessments of facial differences, aiding in understanding developmental impacts.

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Three-Dimensional Shape Modeling and Analysis of Brain Structures

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Three-Dimensional Shape Modeling and Analysis of Brain Structures

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Published on: November 14, 2019

Area of Science:

Biostatistics
Medical Imaging
Developmental Biology

Background:

Facial shape analysis in infants with cleft lip and palate is crucial for understanding developmental trajectories.
High-dimensional longitudinal data present unique analytical challenges.

Purpose of the Study:

To apply novel methods for analyzing high-dimensional longitudinal facial shape data.
To compare facial shape changes over time between infants with cleft lip and palate and controls.

Main Methods:

Utilized a pairwise methodology to apply linear mixed-effects models to high-dimensional facial shape data.
Fitted bivariate linear mixed-effects models to coordinate positions and aggregated results.
Employed B-splines for efficient parameterization of facial curves.

Main Results:

Presented 2D results in profile and frontal views, including bivariate confidence intervals for landmark and curve positions.
Enabled objective assessment of significant facial differences between groups.
Performed model comparison using Wald and pseudolikelihood ratio tests.

Conclusions:

The novel application of high-dimensional longitudinal data analysis methods provides objective insights into facial shape differences.
This approach facilitates a deeper understanding of the impact of cleft lip and palate on facial development.