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Related Experiment Video

Updated: Jul 7, 2026

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Published on: July 14, 2023

PTH-related peptide (PTHrP) in hypercalcemia.

Gregory R Mundy¹, James R Edwards

¹Vanderbilt Center for Bone Biology, 1235 Medical Research Building IV, Nashville, TN 37232-0575, USA. gregory.r.mundy@vanderbilt.edu

Journal of the American Society of Nephrology : JASN

|February 8, 2008

Summary

Parathyroid hormone-related peptide (PTHrP) has advanced our understanding of cancer-related hypercalcemia over 20 years. Targeting PTHrP offers a promising strategy for treating hypercalcemia and bone loss in cancer patients.

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Last Updated: Jul 7, 2026

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

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Published on: July 14, 2023

Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation

Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation

Published on: March 14, 2017

Area of Science:

Endocrinology
Oncology
Molecular Biology

Background:

Parathyroid hormone-related peptide (PTHrP) was identified 20 years ago as a tumor-associated factor.
Significant advancements have been made in understanding hypercalcemic syndromes linked to malignancy.
The role of PTHrP in normal physiology and pathological conditions has been elucidated.

Purpose of the Study:

To review the 20-year progress in understanding parathyroid hormone-related peptide (PTHrP).
To highlight the diagnostic utility of PTHrP in hypercalcemia.
To discuss therapeutic strategies targeting PTHrP in cancer.

Main Methods:

Literature review and synthesis of research over the past two decades.
Analysis of diagnostic applications of PTHrP.
Evaluation of emerging therapeutic approaches targeting PTHrP.

Main Results:

PTHrP is a key factor in malignancy-associated hypercalcemia.
PTHrP serves as a valuable diagnostic marker for hypercalcemia.
Inhibiting PTHrP offers potential for treating cancer-related hypercalcemia and osteolysis.

Conclusions:

The identification of PTHrP has revolutionized the understanding of cancer-associated hypercalcemia.
PTHrP is crucial for both normal physiology and malignancy.
Targeting PTHrP presents a promising therapeutic avenue for managing cancer complications.