Linking mitosis with S-phase: Cdc6 at play

Susanna Boronat1, Judith L Campbell

  • 1Braun Laboratories 147-75, California Institute of Technology, Pasadena, California 91125, USA.

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Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
M cyclin...
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Checkpoints throughout the cell cycle serve as safeguards and gatekeepers, allowing the cell cycle to progress in favorable conditions and slow or halt it in problematic ones. This regulation is known as the cell cycle control system.
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