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Updated: Jul 7, 2026

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
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A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

Published on: April 12, 2017

Cell sensitivity to reaferon in patients with renal cell cancer after reaferon therapy

E A Shkapova1, L M Kurtasova, A A Savchenko

  • 1Krasnoyarsk Territorial Oncological Center, Siberian Division of Russian Academy of Medical Sciences, Krasnoyarsk. k_shkapova@mail.ru

Bulletin of Experimental Biology and Medicine
|February 8, 2008
PubMed

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Renal Failure: Dose Adjustments

In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...