Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Multiple sclerosis in children.

Terrence Thomas1, Brenda Banwell

  • 1Pediatric Multiple Sclerosis Clinic, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

Seminars in Neurology
|February 8, 2008
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The gut microbiome in pediatric-onset acquired demyelinating syndromes by myelin oligodendrocyte glycoprotein antibody status.

Multiple sclerosis and related disorders·2026
Same author

Factors Influencing Early and Late B-Cell Repopulation After Rituximab Therapy in Pediatric Central Nervous System Inflammatory Disorders.

Pediatric neurology·2026
Same author

Higher ultra-processed food consumption is associated with higher likelihood of paediatric-onset multiple sclerosis.

Multiple sclerosis and related disorders·2026
Same author

The Use of Patient-Reported Outcome Measures in Developmental Age: A Complementary Tool for Pediatric Multiple Sclerosis Prognosis.

Neurology and therapy·2026
Same author

Life-Threatening SARS-CoV-2-Associated Encephalopathy and Multiorgan Failure in Children, Asia and Oceania, 2022-2024.

Emerging infectious diseases·2026
Same author

Characteristic patterns of complement deposition in NMOSD, MOGAD, and MS.

Acta neuropathologica·2026
Same journal

Isolated Cranial Tremors: A Reappraisal.

Seminars in neurology·2026
Same journal

Dystonia and Tremor.

Seminars in neurology·2026
Same journal

Pendular nystagmus and oculopalatal tremor.

Seminars in neurology·2026
Same journal

Sanjay Pandey, MBBS, MD, DNB, DM, FIAN, and Aasef Shaikh, MD, PhD.

Seminars in neurology·2026
Same journal

Tremor.

Seminars in neurology·2026
Same journal

Carotid Disease.

Seminars in neurology·2026
See all related articles

Pediatric multiple sclerosis (MS) diagnosis is rising. This article reviews clinical features, diagnostic approaches, and safe immunomodulatory treatments for pediatric MS, highlighting key distinctions from adult MS.

Area of Science:

  • Neurology
  • Pediatrics
  • Immunology

Background:

  • Multiple sclerosis (MS) is increasingly diagnosed in children and adolescents.
  • Pediatric MS shares similarities with adult-onset MS but has unique distinctions.
  • Understanding these differences is crucial for accurate diagnosis and management.

Purpose of the Study:

  • To provide an overview of pediatric multiple sclerosis.
  • To discuss clinical and MRI features specific to pediatric MS.
  • To outline diagnostic criteria and differential diagnoses for childhood MS.

Main Methods:

  • Review of recent clinical definitions and case vignettes.
  • Analysis of magnetic resonance imaging (MRI) findings in pediatric MS.
  • Examination of safety and tolerability data for immunomodulatory therapies in children.

Related Experiment Videos

Main Results:

  • Clinical and MRI features of pediatric MS are largely similar to adult MS, with notable exceptions.
  • Approved immunomodulatory therapies for adults are safe and well-tolerated in children.
  • Liver function monitoring is essential during treatment.

Conclusions:

  • Pediatric MS requires tailored diagnostic and management strategies.
  • Early diagnosis and appropriate treatment are vital for long-term outcomes.
  • Ongoing research explores the relationship between MS pathogenesis and disease onset in specific populations.