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Three-dimensional printing in pharmaceutics: promises and problems.

Deng Guang Yu¹, Li-Min Zhu, Christopher J Branford-White

¹Institute of Biological Sciences and Biotechnology, Donghua University, Shanghai 201620, China.

Journal of Pharmaceutical Sciences

|February 8, 2008

Summary

This summary is machine-generated.

Three-dimensional printing (3DP) offers advanced pharmaceutical applications for creating diverse solid dosage forms. Further research is needed to overcome challenges in excipient selection and product properties for wider adoption.

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Area of Science:

Pharmaceutical Sciences
Materials Engineering
Drug Delivery Technology

Background:

Three-dimensional printing (3DP) is a rapid prototyping technology utilizing powder processing and liquid binding materials.
3DP offers advantages over conventional methods in pharmaceutical applications, including design, development, and manufacturing of solid dosage forms.

Purpose of the Study:

To provide an overview of the potential of 3DP in developing novel drug delivery systems (DDS).
To highlight the flexibility and advantages of 3DP in pharmaceutical applications.
To identify current limitations and areas for future development.

Main Methods:

Literature review of 3DP applications in pharmaceutical solid dosage forms.
Analysis of 3DP's capabilities in creating various drug delivery systems.
Discussion of challenges and future directions for 3DP in pharmaceutics.

Main Results:

3DP technology enables the creation of diverse DDS, including linear, colon-targeted, fast-disintegrating, floating, time-controlled, pulse-release, multiphase-release, and implantable systems.
It addresses challenges in delivering poorly water-soluble drugs, peptides, proteins, potent drugs, and multidrug combinations.
3DP offers advantages in flexibility, reproducibility, and fabrication over conventional methods.

Conclusions:

3DP holds significant potential for advancing pharmaceutical applications and developing innovative drug delivery systems.
Further research is required to address limitations in excipient selection and pharmacotechnical properties for successful integration with conventional pharmaceutics.
Continued development will enable wider application of 3DP in pharmaceutical manufacturing.