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Updated: Jul 7, 2026
Murine Model for Parkinson's Disease: from 6-OH Dopamine Lesion to Behavioral Test
Published on: January 15, 2010
[Effects of scalp catgut embedding on SOD, NO, MDA in the rat with Parkinson's disease]
Xiao-Xia Xie1, Suo-Tang Kou, Zhi-Hong Pu
1Gansu Hospital of Health Care of Cadres, Lanzhou 730020, China. xie6761@126.com
Objective:
To explore the mechanism of scalp catgut embedding for treatment of Parkinson's disease.
Methods:
Parkinson's disease model rats were prepared, and randomly divided into a model group, scalp acupuncture group, medication group, with a control group set up. The scalp acupuncture group were treated with catgut embedding at "the chorea-trembling conroued area" lateral to "Baihui" (GV 20) and the medication group with intra-gastric perfusion of L-dopa suspension. After treatment for 30 days, behavior indexes were investigated and malondialdehyde (MDA) and nitric oxide (NO) contents and superoxide dismutase (SOD) activity in the brain were detected.
Results:
MDA content in the brain of the model rats were significantly decreased (P < 0.01), NO level significantly increased (P < 0.05) by scalp catgut embedding, with no significant change of SOD activity (P > 0.05); and the behavior indexes and tissue and form of the brain had significant improvement.
Conclusion:
Scalp catgut embedding has regulative action on anti-oxidant enzyme system in the Parkinson's disease rats, has significant improvement of cells, tissues and form of the brain.
