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Related Experiment Video

Updated: Jul 7, 2026

A Cognitive Fusion-guided Prostate Biopsy Using Multiparametric Magnetic Resonance Imaging and Transrectal Ultrasound
06:08

A Cognitive Fusion-guided Prostate Biopsy Using Multiparametric Magnetic Resonance Imaging and Transrectal Ultrasound

Published on: March 21, 2025

[New markers in prostate biopsies].

V Molinié1, H Baumert

  • 1Department of Pathology, Hôpital Saint-Joseph, Paris, France. vmolinie@hpsj.org

Actas Urologicas Espanolas
|February 9, 2008
PubMed
Summary
This summary is machine-generated.

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Serum prostate-specific antigen screening increases prostate needle biopsies, leading to more ambiguous lesions. This review discusses histological features and new markers like AMACR for diagnosing small prostate cancer foci.

Area of Science:

  • Uropathology
  • Oncology
  • Immunohistochemistry

Context:

  • Increased prostate needle biopsies due to PSA screening yield more ambiguous lesions.
  • Distinguishing small foci of malignancy from benign mimickers is challenging for pathologists.
  • Basal cell markers (p63, 34betaE12) aid in identifying benign glands but have limitations.

Purpose:

  • To review histological features of small prostate cancer foci.
  • To discuss the utility of novel immunohistochemical markers, including alpha-methyl-coenzyme-A-racemase (AMACR), in diagnosing ambiguous prostate lesions.
  • To highlight best practice guidelines for evaluating prostate needle biopsies.

Summary:

  • Prostate-specific antigen (PSA) screening has increased prostate needle biopsies, resulting in a rise of ambiguous lesions requiring careful pathological examination.

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Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
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Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

Published on: November 2, 2013

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Last Updated: Jul 7, 2026

A Cognitive Fusion-guided Prostate Biopsy Using Multiparametric Magnetic Resonance Imaging and Transrectal Ultrasound
06:08

A Cognitive Fusion-guided Prostate Biopsy Using Multiparametric Magnetic Resonance Imaging and Transrectal Ultrasound

Published on: March 21, 2025

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
13:19

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

Published on: November 2, 2013

  • Immunohistochemical stains for basal cell markers are valuable but can be negative in benign mimickers, necessitating further diagnostic tools.
  • Alpha-methyl-coenzyme-A-racemase (AMACR) shows promise as a sensitive marker for confirming malignancy in ambiguous prostate lesions, though sensitivity and specificity challenges remain.

    • Impact:

    • Improves diagnostic accuracy for small prostate cancer foci on needle biopsy.
    • Provides guidance on utilizing new markers to reduce misdiagnosis.
    • Aids pathologists in making definitive diagnoses, impacting patient management and treatment decisions.