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Updated: Jul 7, 2026
Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice
Published on: October 10, 2025
Mortality and morbidity of neonates born at <26 weeks of gestation (1998-2003). A population-based study
Eva Landmann1, Björn Misselwitz, Jens O Steiss
1Pediatric Center, Department of Pediatrics and Neonatology, Giessen, Germany. Eva.Landmann@paediat.med.uni-giessen.de
Objective:
To describe mortality and morbidity of neonates born at <26 weeks' gestation in a contemporary population-based cohort.
Methods:
We analyzed data of neonates born at <26 weeks between 1998 and 2003 in the Federal State of Hesse, Germany. Survival was calculated at 28 days and at discharge from hospital.
Results:
Out of a total of 800 births, 572 infants were liveborn. Among those admitted for neonatal intensive care, 62.3% survived until day 28. Among the neonates followed until death or discharge, 59.6% were discharged home. Logistic regression analyses showed the following variables to be associated with an increased risk of death: Twins (Odds Ratio (OR) 3.7; 95% Confidence Interval (CI) 1.34-10.26), multiple birth >or=3 (OR 8.14; CI 1.23-53.86), intraventricular hemorrhage (IVH) >or=grade III (OR 4.79; CI 1.89-12.14), clinical risk index for babies score >15 (OR 2.9; CI 1.09-7.76), and a gestational age
Conclusions:
This study provides outcome data derived from a contemporary population-based cohort. Mortality and complication rates remain high.
