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Super-sentinel chickens and detection of low-pathogenicity influenza virus
Philip I Marcus1, Theodore Girshick, Louis van der Heide
1Department of Molecular and Cell Biology, University of Connecticut, U-3125, 75 North Eagleville Rd, Storrs, CT 06269, USA. philip.marcus@uconn.edu
Abstract:
Chicken interferon-alpha administered perorally in drinking water acts on the oropharyngeal mucosal system as an adjuvant that causes chickens to rapidly seroconvert after natural infection by low-pathogenicity Influenza virus. These chickens, termed super sentinels, can serve as sensitive early detectors of clinically inapparent infections.
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