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Ciprofloxacin-resistant Neisseria meningitidis, Delhi, India

Smita Singhal1, Kedar P Purnapatre, Vandana Kalia

  • 1Ranbaxy Research Laboratories, Gurgaon, India.

Emerging Infectious Diseases
|February 9, 2008
PubMed

Insights

Ciprofloxacin resistance in Neisseria meningitidis emerged during a Delhi outbreak. Antimicrobial susceptibility testing and DNA gyrase sequencing confirmed this concerning development in meningococcal isolates.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • Neisseria meningitidis is a significant bacterial pathogen causing meningitis and sepsis.
  • Antimicrobial resistance poses a growing threat to public health globally.
  • Ciprofloxacin is a crucial antibiotic for treating bacterial infections.

Purpose of the Study:

  • To investigate the emergence of decreased susceptibility to ciprofloxacin in Neisseria meningitidis isolates.
  • To confirm the presence and mechanisms of ciprofloxacin resistance in meningococcal strains from a specific outbreak.

Main Methods:

  • Antimicrobial susceptibility testing was performed on Neisseria meningitidis isolates.
  • DNA gyrase A quinolone-resistance-determining region was sequenced to identify resistance mutations.

Main Results:

  • Neisseria meningitidis isolates from a Delhi outbreak showed decreased susceptibility to ciprofloxacin.
  • Genetic analysis confirmed the presence of mutations associated with ciprofloxacin resistance.

Conclusions:

  • Ciprofloxacin resistance has emerged in Neisseria meningitidis isolates.
  • This finding highlights the need for ongoing surveillance of antimicrobial resistance in meningococcal disease.

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