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Genome-wide RNAi Screening to Identify Host Factors That Modulate Oncolytic Virus Therapy

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WU polyomavirus in children, Canada.

Yacine Abed¹, David Wang, Guy Boivin

¹Centre Hospitalier Universitaire de Québec and Research Center in Infectious Diseases, Quebec City, Quebec, Canada.

Emerging Infectious Diseases

|February 9, 2008

Summary

This summary is machine-generated.

WU polyomavirus was found in Canadian children with respiratory infections and asymptomatic children. Genetic analysis revealed similarities to Australian and American strains, but its role in disease remains unclear.

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Merkel Cell Polyomavirus Infection and Detection

Merkel Cell Polyomavirus Infection and Detection

Published on: February 7, 2019

Area of Science:

Virology
Pediatric Respiratory Infections
Public Health

Background:

WU polyomavirus (WU polyomavirus) is a human polyomavirus.
Its prevalence and role in respiratory infections, especially in children, are not well understood.
Previous studies have suggested potential associations with respiratory illness.

Purpose of the Study:

To investigate the presence of WU polyomavirus in children with respiratory infections and asymptomatic children in Canada.
To characterize the genetic relationship of detected WU polyomavirus strains to other global isolates.

Main Methods:

Nasopharyngeal aspirates were collected from children during a specific winter season.
Polymerase chain reaction (PCR) was used to detect WU polyomavirus DNA.
Large T antigen (TAg) and VP2 genes were sequenced for phylogenetic analysis.

Main Results:

WU polyomavirus was detected in 2.5% of children with respiratory infections (n=2/79) and 6.4% of asymptomatic children (n=5/78).
All detected strains were genetically similar to WU polyomavirus strains found in Australia and the United States.
Respiratory syncytial virus (RSV) was identified in the two infected children.

Conclusions:

WU polyomavirus circulates in the Canadian pediatric population, affecting both symptomatic and asymptomatic individuals.
The genetic data suggest limited geographic diversity for WU polyomavirus strains.
Further research is needed to elucidate the pathogenic role of WU polyomavirus in pediatric respiratory diseases.