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Related Experiment Video

Updated: Jul 7, 2026

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks

Published on: June 26, 2020

Hepatitis E in England and Wales.

Hannah C Lewis¹, Sophie Boisson, Samreen Ijaz

¹Emerging Infections and Zoonoses Department, Centre for Infections, Health Protection Agency, 61 Colindale Avenue, London, United Kingdom.

Emerging Infectious Diseases

|February 9, 2008

Summary

This summary is machine-generated.

Hepatitis E virus infections are occurring in England and Wales. Consider Hepatitis E in patients with hepatitis, even without a travel history, as indigenous cases are confirmed.

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Area of Science:

Hepatology
Infectious Diseases
Public Health Virology

Background:

Hepatitis E virus (HEV) is a significant cause of acute hepatitis globally.
While often associated with travel to endemic areas, indigenous transmission is increasingly recognized.

Purpose of the Study:

To analyze the epidemiology of Hepatitis E virus infections in England and Wales in 2005.
To highlight the importance of considering indigenous HEV infections in differential diagnoses.

Main Methods:

Retrospective analysis of confirmed hepatitis cases in England and Wales during 2005.
Categorization of cases into travel-related and indigenous infections.

Main Results:

A total of 329 hepatitis E virus infections were confirmed.
33 cases were confirmed as indigenous infections, with an additional 67 estimated to be indigenous.
These findings indicate a notable burden of indigenous HEV in the studied population.

Conclusions:

Hepatitis E virus infection is an established and relevant diagnosis in England and Wales.
Healthcare providers should consider HEV in patients presenting with hepatitis, irrespective of their travel history.
Further surveillance and research are warranted to understand the full scope of indigenous HEV transmission.