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Adamantane-resistant influenza infection during the 2004-05 season

Mahbubur Rahman1, Rick A Bright, Burney A Kieke

  • 1Epidemiology Research Center (ML2), Marshfield Clinic Research Foundation, 1000 N. Oak Avenue, Marshfield, WI 54449, USA.

Emerging Infectious Diseases
|February 9, 2008
PubMed

Insights

Adamantane resistance in influenza A viruses is common, particularly in children. Resistant and susceptible strains cause similar illness severity and duration, indicating a need for alternative treatments.

Area of Science:

  • Virology
  • Epidemiology
  • Public Health

Background:

  • Adamantane resistance in influenza A is an increasing concern.
  • Limited comparative data exists between infections caused by adamantane-resistant and susceptible influenza A viruses.
  • Influenza A virus (H3N2) is a significant cause of seasonal respiratory illness.

Purpose of the Study:

  • To compare the clinical characteristics of infections caused by adamantane-resistant and susceptible influenza A viruses.
  • To determine the prevalence of adamantane resistance in influenza A virus isolates.
  • To identify demographic groups with a higher prevalence of adamantane resistance.

Main Methods:

  • Analysis of 152 influenza A virus (H3N2) isolates collected in 2005.
  • Phenotypic or genotypic testing to determine adamantane resistance.
  • Comparison of symptom profiles and illness duration between patients infected with resistant and susceptible viruses.

Main Results:

  • 47% of the analyzed influenza A virus (H3N2) isolates exhibited adamantane resistance.
  • No significant differences were observed in symptom presentation or duration of illness between infections caused by resistant and susceptible viruses.
  • The prevalence of adamantane resistance was notably higher in pediatric populations.

Conclusions:

  • Adamantane resistance is prevalent in seasonal influenza A (H3N2) viruses.
  • Clinical outcomes do not differ significantly between infections with resistant and susceptible strains.
  • The high prevalence in children suggests a potential need for reassessing treatment guidelines, especially for pediatric influenza cases.

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