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Updated: Jul 7, 2026
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Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
Published on: February 19, 2021
Coagulation status and biochemical and inflammatory markers in multiple sclerosis
Fehime B Aksungar1, Aynur E Topkaya, Zeynep Yildiz
1Department of Biochemistry, School of Medicine, Maltepe University, Atatürk Caddesi, Cam Sokak No. 3/A, Istanbul, Turkey. fehimebenli@gmail.com
Summary
Multiple sclerosis (MS) patients show altered coagulation and biochemical markers. Elevated homocysteine and D-dimer levels were positively correlated, suggesting potential links in MS pathogenesis.
Area of Science:
- Neurology
- Immunology
- Biochemistry
Background:
- Multiple sclerosis (MS) is a leading cause of neurologic disability in young adults.
- It is characterized by inflammation and demyelination in the central nervous system.
Purpose of the Study:
- To investigate coagulation status and biochemical/inflammatory markers in MS patients.
- To explore potential correlations between these markers and MS.
Main Methods:
- Measured plasma prothrombin time, activated partial thrombin time, fibrinogen, D-dimer, hs-CRP, homocysteine, BUN, creatinine, calcium, total protein, albumin, cholesterol, vitamin B12, folate, and ESR.
- Compared 42 MS patients with 31 healthy controls.
Main Results:
- MS patients had lower serum total protein, albumin, and calcium levels compared to controls.
- A significant positive correlation was found between homocysteine and D-dimer levels (r=0.84, p<0.01).
- No significant correlation was observed between homocysteine and vitamin B12 or folate levels.
Conclusions:
- MS patients exhibit alterations in coagulation and biochemical profiles.
- These findings may enhance understanding of MS etiopathogenesis and clinical features.
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