Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Lipid-derived Compounds in the Human Body01:31

Lipid-derived Compounds in the Human Body

Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various  biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin, delayed...
Inflammatory Response01:28

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation01:38

Inflammation

Overview
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
Biosynthesis of Lipids01:29

Biosynthesis of Lipids

Microbial membranes exhibit remarkable diversity in lipid composition, reflecting evolutionary adaptations to various environmental conditions. The three domains of life—Bacteria, Archaea, and Eukarya—synthesize membrane lipids through distinct biosynthetic pathways, leading to fundamental structural differences that impact membrane stability, function, and adaptability.Fatty Acid-Based Lipids in Bacteria and EukaryaBacteria and eukaryotes share a common fatty acid biosynthesis pathway, which...
Acute Inflammation III: Local and Systemic Effects01:25

Acute Inflammation III: Local and Systemic Effects

Acute inflammation produces a coordinated set of local and systemic changes that limit injury, eliminate pathogens, and initiate repair. These responses arise within minutes of infection, trauma, or chemical insult and are driven by vascular alterations and leukocyte-derived mediators. When the stimulus resolves, the reaction typically abates within days.Local EffectsAt the site of injury, arteriolar vasodilation increases blood flow, resulting in redness and warmth. Simultaneously, increased...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Modeling Neuroimmunological Interactions at the Blood-Brain Barrier Using In Vitro 3D Human Organoids: Inflammation and Ischemia-Reperfusion Injury.

Cells·2026
Same author

Hydrolysis and depletion of phosphatidylglycerol at peak murine acute lung injury.

Journal of lipid research·2026
Same author

Effect of Dietary Linoleic Acid Intake on Eicosapentaenoic Acid Status and Lipoxygenase-Mediated Oxylipin Biosynthesis in Healthy Adults: A Randomized Controlled Trial.

Nutrients·2026
Same author

A Pilot Feasibility Study of a Group-Based Remote-Delivered Dyadic Exercise Intervention in Hispanic Men With Prostate Cancer and Their Caregivers.

Cancer medicine·2026
Same author

A human airway-on-a-chip microphysiological system for modeling chlorine gas toxicity.

Toxicological sciences : an official journal of the Society of Toxicology·2025
Same author

The Impact of Fatty Acid Reporting Methods on Associations with Cardiometabolic Biomarkers.

medRxiv : the preprint server for health sciences·2025

Related Experiment Videos

Mechanisms by which botanical lipids affect inflammatory disorders.

Floyd H Chilton1, Lawrence L Rudel, John S Parks

  • 1Center for Botanical Lipids, Wake Forest University, Winston Salem, NC, USA. schilton@wfubmc.edu

The American Journal of Clinical Nutrition
|February 9, 2008
PubMed
Summary

Dietary fatty acid changes are linked to increased inflammatory diseases. Botanical lipid supplements, like echium oil, show promise in inhibiting inflammation and potentially treating conditions such as cardiovascular disease and asthma.

Related Experiment Videos

Area of Science:

  • Nutritional Science
  • Biochemistry
  • Molecular Biology

Background:

  • Dietary fatty acid consumption has shifted significantly over the last century, with increased saturated and n-6 fatty acids and decreased n-3 fatty acids.
  • This dietary shift is a suspected major contributor to the rising incidence of inflammatory conditions, including asthma, allergies, and atherosclerosis.
  • Understanding the mechanisms by which dietary lipids influence inflammation is crucial for developing effective disease prevention and treatment strategies.

Purpose of the Study:

  • To investigate the mechanisms by which botanical fatty acid supplements inhibit inflammation.
  • To determine if botanical n-6 and n-3 fatty acids directly interfere with biochemical pathways or gene expression linked to asthma and atherosclerosis.
  • To explore the potential of specific botanical oils and their combinations in managing chronic inflammatory diseases.

Main Methods:

  • Utilizing dietary supplementation with flaxseed oil, borage oil, and echium oil in relevant models.
  • Analyzing the effects of these oils on fatty acid metabolism and the balance of pro-inflammatory mediators and lipids.
  • Investigating key molecular and genetic pathways influenced by lipid metabolism in inflammatory and hyperlipidemic diseases.

Main Results:

  • Supplementation with flaxseed, borage, and echium oils alters fatty acid metabolism and influences the production of inflammatory mediators and atherogenic lipids.
  • Studies are identifying specific molecular and genetic targets involved in lipid mediator regulation relevant to inflammatory diseases.
  • Echium oil, rich in stearidonic acid, and botanical oil combinations demonstrate potential in modulating inflammatory processes.

Conclusions:

  • Botanical fatty acid supplements can modulate lipid metabolism and inflammatory pathways.
  • Echium oil and specific botanical oil combinations show promise as therapeutic agents for inflammatory and hyperlipidemic diseases.
  • Further research into the molecular and genetic mechanisms is warranted to fully harness the potential of these botanical lipids.