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Related Concept Videos

Bone Formation by Endochondral Ossification01:24

Bone Formation by Endochondral Ossification

Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
Growth of Cartilage and Bone Tissue01:27

Growth of Cartilage and Bone Tissue

Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...

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Related Experiment Video

Updated: Jul 7, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
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Ossifying chondroid lipoma.

Benjamin Hoch1, George Hermann, Michael J Klein

  • 1Department of Pathology, Mount Sinai Medical Center, P.O. Box 1194, One Gastave L. Levy Place, New York, NY 07422, USA. benjamin.hoch@mountsinai.org

Skeletal Radiology
|February 9, 2008
PubMed
Summary
This summary is machine-generated.

Chondroid lipoma, a rare tumor, can mimic sarcoma. This case highlights its unusual imaging features, including bone formation, aiding diagnosis.

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Published on: January 23, 2018

Area of Science:

  • Oncology
  • Radiology
  • Pathology

Background:

  • Chondroid lipoma is a rare lipoma variant that can be misdiagnosed as sarcoma.
  • Imaging diagnosis is challenging due to heterogeneous features and limited collective data.

Observation:

  • A 37-year-old woman presented with an upper thigh soft tissue mass.
  • Radiological findings included a large mass with calcification and ossification.

Findings:

  • The chondroid lipoma exhibited metaplastic bone formation, a rare occurrence in this tumor type.
  • Histopathology confirmed the diagnosis, correlating with imaging findings.

Implications:

  • This case expands the understanding of chondroid lipoma's imaging spectrum.
  • Recognizing ossification in chondroid lipoma is crucial for accurate diagnosis and avoiding misclassification as sarcoma.