TAE226 inhibits human neuroblastoma cell survival
Elizabeth A Beierle1, Angelica Trujillo, Abhilasha Nagaram
1Department of Surgery, University of Florida, Gainesville, Florida 32610-0286, USA. beierea@surgery.ufl.edu
Purpose:
Neuroblastoma is one of the most devastating pediatric solid tumors and is unresponsive to many interventions. TAE226 is a novel small molecule FAK inhibitor. We investigated the effects of TAE226 on neuroblastoma cells in vitro.
Materials And Methods:
Human neuroblastoma cell lines were treated with varying concentrations of TAE226. Following treatment, cell viability, cell cycle, and apoptosis were evaluated.
Results:
Treatment of human neuroblastoma cell lines with TAE226 resulted in a concentration dependent decrease in FAK phosphorylation, decrease in cellular viability, cell cycle arrest, and an increase in apoptosis.
Conclusions:
Targeting FAK provides potential therapeutic options for the treatment of neuroblastoma and deserves further investigation.
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