Related Experiment Video
Updated: Jul 7, 2026
Establishment and Propagation of Human Retinoblastoma Tumors in Immune Deficient Mice
Published on: August 4, 2011
[Congenital mature teratoma of the right orbit]
J K Kohlhof1, O Driemel, U Müller-Richter
1Klinik und Poliklinik für Augenheilkunde, Universitätsklinikum Regensburg.
Background:
Teratomas are congenital embryonic tumours composed of a wide diversity of tissues derived from the three germinal layers (ectoderm, mesoderm, endoderm). Located in the orbit they endanger the eye and the bony structures. The main goal of treatment is preservation of the eye. In most cases this will not be feasible.
Case Report:
A newborn boy was admitted to our hospital because of a prenatally known protrusion of the right globe. On examination the baby had a large retrobulbar orbital tumour, which displaced the globe ventrally. On MRI the tumour had an extent of 5 cm. It compromised the frontal bone and reached intracranially. No other malformations were found. The tumour was transorbitally resected and the eye exenterated. A congenital mature teratoma was diagnosed. To preserve orbital volume an implant was inserted (Hema globe, 18 mm).
Follow-Up:
The healing course was uneventful. Illig implants were changed without difficulties. After 10 months an individual prosthesis was inserted. Control CT scans showed no signs of tumour.
Conclusions:
The case presented underlines the possible extent and impact of congenital mature teratomas. Despite the extent of the tumour and the very young age of the patient a satisfactory treatment result was achieved.
Related Concept Videos
01:20The Retinoblastoma Gene
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
01:20The Retinoblastoma Gene
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
01:17Accessory Structures of the Eye
01:14Cranial Bones: Superior and Posterior View
The frontal bone is the single bone that forms the forehead. At its anterior midline, between the eyebrows, there is a slight depression called the glabella. The frontal bone also forms the supraorbital margin of the orbit. Near the middle of this margin is the supraorbital foramen, the opening that provides passage for a sensory nerve to the forehead. The frontal bone is thickened just above each supraorbital margin,...
01:27Cranial Bones: Lateral View
The temporal bone forms the lower lateral side of the skull. The temporal bone is subdivided into several regions. The flattened upper portion is the squamous portion of the temporal bone. Below this area and projecting anteriorly is the zygomatic process of the temporal bone, which forms the posterior portion of the zygomatic arch. Posteriorly is the mastoid portion of the temporal bone. Projecting...