Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bacterial Meningitis I: Introduction01:22

Bacterial Meningitis I: Introduction

Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
Bacterial Meningitis01:24

Bacterial Meningitis

Bacterial meningitis is a severe infectious disease involving inflammation of the meninges, the protective membranes surrounding the brain and spinal cord. It occurs when pathogenic bacteria cross the blood–brain barrier and enter the cerebrospinal fluid. Common causative organisms include Neisseria meningitidis, Streptococcus pneumoniae, Haemophilus influenzae type b, Listeria monocytogenes, and Escherichia coli K1. The exact route of entry varies by pathogen and host condition.Routes of Entry...
Bacterial Meningitis II: Pathophysiology01:26

Bacterial Meningitis II: Pathophysiology

Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...
Viral Meningitis01:18

Viral Meningitis

Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
Encephalitis l: Introduction01:19

Encephalitis l: Introduction

Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Predicting late radiation-associated neurocognitive and endocrine toxicity in patients with brain tumors.

Journal of neuro-oncology·2026
Same author

MGMTai: O6-methylguanine-DNA methyltransferase (<i>MGMT</i>) methylation prediction in isocitrate dehydrogenase (<i>IDH</i>)-wild type glioblastoma to direct temozolomide therapy.

Neuro-oncology advances·2026
Same author

Fusion transcriptome landscape in glioblastoma: Incidence and therapeutic implications.

Neuro-oncology advances·2026
Same author

BNIP3-mTOR Signaling Mediates Resistance to MET Inhibition in Glioblastoma.

bioRxiv : the preprint server for biology·2026
Same author

Prophylactic Intraventricular Vancomycin: A Potential Paradigm Shift in Ommaya Reservoir-Associated Infection Prevention.

World neurosurgery·2025
Same author

Intra-Ommaya reservoir administration technique affects cerebrospinal fluid drug distribution in patients with leptomeningeal metastases.

Neuro-oncology practice·2025

Related Experiment Video

Updated: Jul 7, 2026

Minimally Invasive Cisterna Magna Injection Model for Leptomeningeal Metastasis Studies in Mice
07:14

Minimally Invasive Cisterna Magna Injection Model for Leptomeningeal Metastasis Studies in Mice

Published on: May 23, 2025

Myelomatous meningitis.

Marc C Chamberlain1, Michael Glantz

  • 1Department of Neurology, University of Washington, Fred Hutchinson Cancer Center, Seattle, Washington 98109, USA. ChambeMC@u.washington.edu

Cancer
|February 9, 2008
PubMed
Summary
This summary is machine-generated.

Myelomatous meningitis (MM) is a rare complication of multiple myeloma. This study found MM to be a morbid entity with poor response to treatment and a low survival rate.

More Related Videos

A Murine Ommaya Xenograft Model to Study Direct-Targeted Therapy of Leptomeningeal Disease
07:17

A Murine Ommaya Xenograft Model to Study Direct-Targeted Therapy of Leptomeningeal Disease

Published on: January 29, 2021

Related Experiment Videos

Last Updated: Jul 7, 2026

Minimally Invasive Cisterna Magna Injection Model for Leptomeningeal Metastasis Studies in Mice
07:14

Minimally Invasive Cisterna Magna Injection Model for Leptomeningeal Metastasis Studies in Mice

Published on: May 23, 2025

A Murine Ommaya Xenograft Model to Study Direct-Targeted Therapy of Leptomeningeal Disease
07:17

A Murine Ommaya Xenograft Model to Study Direct-Targeted Therapy of Leptomeningeal Disease

Published on: January 29, 2021

Area of Science:

  • Neurology
  • Oncology
  • Hematology

Background:

  • Nervous system complications in multiple myeloma (MM) include peripheral neuropathy and spinal cord compression.
  • Myelomatous meningitis (MM) is considered a rare complication of MM.

Purpose of the Study:

  • To characterize the clinical presentation of MM.
  • To define the treatment strategies for MM.
  • To evaluate the outcomes of MM patients.

Main Methods:

  • A case series of 14 patients with cerebrospinal fluid (CSF)-positive MM.
  • Treatment involved involved-field radiotherapy and intra-CSF chemotherapy.
  • Patients were treated at a tertiary care university medical center.

Main Results:

  • Six partial responses and 8 patients with progressive disease were observed.
  • The median duration of response was 2.5 months.
  • Causes of death included progressive neurologic disease, combined systemic and neurologic disease, and systemic disease progression.

Conclusions:

  • MM is a rare and morbid entity with a 6-month progression-free survival rate of 7%.
  • MM appears to have a similar treatment response rate as solid tumor carcinomatous meningitis.