Comparative studies on parenteral and intranasal inoculation of an attenuated feline herpes virus

Using a temperature sensitive mutant of feline herpes virus, comparative studies were carried out regarding efficacy of the intramuscular and the intranasal routes of administration of virus in inducing resistance to feline rhinotracheitis disease. Susceptible adult animals and kittens with and without parental immunity were used. Resistance to disease was measured by serological and challenge methods. Results in terms of rapidity or induced resistance or immunity as well as the degree and duration of immunity are discussed.