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[Cardiovascular and the other complication followed with Kawasaki disease]

Takashi Soga1, Shigeru Uemura

  • 1Children's Medical Center, Showa University, Northern Yokohama Hospital.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|February 12, 2008
PubMed

Insights

Kawasaki disease (KD) can lead to serious cardiovascular complications like coronary artery aneurysms, even causing sudden death in children. This review details the systemic vasculitis and organ involvement following KD.

Area of Science:

  • Pediatric Cardiology
  • Immunology
  • Vascular Biology

Context:

  • Kawasaki disease (KD) was initially viewed as self-limiting with a good prognosis.
  • However, reports of sudden death post-KD highlighted severe cardiovascular sequelae.
  • KD is now the leading cause of acquired heart disease in childhood, surpassing rheumatic fever.

Purpose:

  • To summarize the cardiovascular and systemic organ complications associated with Kawasaki disease.
  • To elucidate the pathological mechanisms, including systematic vasculitis affecting various arteries.
  • To update the understanding of KD's impact on pediatric cardiovascular health.

Summary:

  • Kawasaki disease (KD) can induce myocardial infarction in infants and children.
  • Cardiovascular complications primarily involve coronary arterial aneurysms, but aneurysms in iliac and subaxial arteries can also occur.
  • Systematic vasculitis affecting medium and small arteries throughout the body is a hallmark of KD, leading to multi-organ involvement.

Impact:

  • Highlights the critical need for early diagnosis and management of KD to prevent long-term cardiovascular damage.
  • Emphasizes KD as a significant pediatric acquired heart disease, necessitating ongoing research and clinical attention.
  • Provides a comprehensive overview for clinicians and researchers on the diverse complications of Kawasaki disease.

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