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Updated: Jul 7, 2026

Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis
Published on: December 17, 2010
Immunological and clinical aspects of lymphocytic hypophysitis
Annamaria De Bellis1, Giuseppe Ruocco, Marina Battaglia
1Department of Clinical and Experimental Medicine and Surgery, "F. Magrassi, A. Lanzara", Second University of Naples, Naples 80131, Italy. annamaria.debellis@unina2.it
Abstract:
LYH (lymphocytic hypophysitis) is an autoimmune disease of the pituitary gland which can present with varying degrees of pituitary hormonal impairment and/or with symptoms related to pituitary enlargement. In this review, we provide an overview of the epidemiology, diagnosis, pathogenesis, treatment, and the role of organ-specific and antipituitary antibodies as potential markers of LYH. In addition, although the mechanisms underlying LYH are not completely understood, the role of prolactin, which plays an important part in maintaining immune system homoeostasis and is increased in the disease, is considered.
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